Ben's Wicked Popular Inhibition Song!!

Note: the actually singing starts around 2:00. UCLA Chem 153A Winter '08 with Dr. Villa. This is the grand finale of extra-credit performances during the last lecture, starring Ben. This guy's awesome!Lyrics provided by Ben himself:[Inhibition! ...To the tune of Popular]When I studied for the midterm I'd forgotten to addressThe topic that I skimmed through and bombed it on the testI see it and my tender heart still criesThen Professor Villa said there'd beAn extra opportunityTo show we'd learn that topic if we triedNow this I must admitI'd underestimated it a bitThat topic that I'd failed so to defineI've opened my mind to learn theNature of In-Hibitors! Enzymatic inhibitorsCounted there're three different kinds That reversibly bindAnd the irreversablesResemblance of most substratesReact at slower ratesSome don't even react at allNow I must beginCompetitive InhibitionSubstrate and inhibitor fightFor the active siteApparent Km turns out highNow we know we can kiss that free energy change goodbyeBut also know apparent Vmax doesn't changeSubstrate concentrations overcome at higher rangeUnlike the uncompetatives that come out strangeBecause it's slower, Apparent Km's lowerNow let us see mechanismsFor uncompetitive inhibitionsInhibitor never winsIf substrate's not inThe E-S complex like we hear, well, heardKm over Alpha prime goesUp through rule Le Chatlier, erLa la, It works great, La la, With more substrateWhich makes the product fail to makeInhibition mixed you'll see onesMove in either or directionsBinds to enzyme-substrate complexOr free enzymes, Raising up apparent KmsWhile apparent Vmax drops happen to themIs that not suicidalThat can't be rightThat's irreversible! Please!Irreversible inhibitorsThey never come out the sameCause they chemically changeNever changing back you'll seeForever it inhibits the enzyme activity- Because irreversible inhibitors permanently bind to or damage essential functional groups and may also form a stable noncovalent complex with the enzyme, inhibition cannot therefore be reversed inhibiting most or all binding of the substrate so that the final product will never form which I won't go into because there was only one slide on irreversible inhibitors and I just said everything that was on there.It was so much funLearning inhibitionI know now not to cramI'm gonna mind and grind itWhen comes the final day's examLa la la la, BiochemistryJust got way less complicated to me!

Channel: Music
Uploaded: November 30, 1999 at 12:00 am
Author: bertckliu

Length: 06:16
Rating: 4.826087
Views: 8891

Tags: UCLA  Biochemistry  extra  credit  Ben  inhibition  inhibitor  

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